Appropriate vitamin B12 levels are key to a healthy pregnancy. Maintaining adequate vitamin B12 levels may support your bone health. One study in more than 2, adults showed that people with a vitamin B12 deficiency also had lower than normal bone mineral density 5. Bones with decreased mineral density can become delicate and fragile over time, leading to an increased risk of osteoporosis. Other studies have also shown a link between low vitamin B12 levels and poor bone health and osteoporosis, especially in women 6 , 7 , 8.
Vitamin B12 may play a vital role in your bone health. Low blood levels of this vitamin have been associated with an increased risk of osteoporosis. Maintaining adequate levels of vitamin B12 may help prevent the risk of age-related macular degeneration. Researchers believe that supplementing with vitamin B12 may lower homocysteine, a type of amino acid that is found in your bloodstream. Elevated homocysteine levels have been associated with an increased risk of age-related macular degeneration 9 , A study involving 5, women aged 40 or older concluded that supplementing with vitamin B12, along with folic acid and vitamin B6, may reduce this risk The group receiving these supplements for seven years had fewer cases of macular degeneration, compared to the placebo group.
Maintaining adequate levels of vitamin B12 decreases homocysteine levels in your blood. This may help prevent the development of age-related macular degeneration.
The effect of vitamin B12 on mood is not yet fully understood. However, this vitamin plays a vital role in synthesizing and metabolizing serotonin, a chemical responsible for regulating mood. Therefore, vitamin B12 deficiency may lead to decreased serotonin production, which may cause a depressed mood. Studies support the use of vitamin B12 supplements for improving symptoms of depression in people deficient in this vitamin. One study in people with depression and low vitamin B12 levels found that those who received both antidepressants and vitamin B12 were more likely to show improved depressive symptoms, compared to those treated with antidepressants alone Another study discovered that vitamin B12 deficiency was associated with twice the risk of severe depression Additionally, high vitamin B12 levels have been linked to better treatment outcomes and an increased probability of recovery from major depressive disorder MDD Though vitamin B12 supplements may help improve mood and depression in people with a deficiency, research does not currently suggest that they have the same effect in those with normal B12 levels.
Vitamin B12 is needed for the production of serotonin, a chemical responsible for regulating mood. Vitamin B12 supplements may help improve mood in people with an existing deficiency. This content does not have an Arabic version. See more conditions. Vitamin B Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information.
Please try again. Something went wrong on our side, please try again. Show references Vitamin B Fact sheet for professionals. Office of Dietary Supplements. Accessed Jan. Fairfield KM. Vitamin supplementation in disease prevention. They are not listed in the B reviews.
Are they safe? Are they effective? However, there do not appear to be any published, controlled clinical studies demonstrating whether these patches are safe and effective, or comparing the use of these patches to oral B supplementation.
Replacement B for gastric disease or or dietary deficiency is one thing. But when a person needs pharmacologic doses of B along with folate and B-6 to lower dangerous levels of homocysteine, the recommended dietary allowances do not apply. There should not be a single interpretation for B requirements based on correcting deficiencies. B absorption required for administration of higher amounts of B in people with homocysteine elevation must be considered separately.
I would like to see if oral lozenges are better in that other circumstance. More generally, I would like to see Consumerlab. Hi William - As you note, the recommended daily allowance applies only to maintaining adequate levels of vitamins and minerals, not treating deficiency. Higher amounts are required to treat deficiency, and this is clearly noted in our Reviews. Regarding your interest in lozenges, there does not seem to be any evidence suggesting that these would be a better way to take B vitamins.
Thank you. My main interest in making that comment, though, was not in treating deficiencies but in the use of some of the metabolic functions of these nutrients at super "normal" levels to treat other diseases or to prevent diseases not normally associated with a deficiency of that nutrient.
An example would be vitamin D3, which has a very low minimal requirement for bone health, but which requires sometimes ten times as much to achieve its effects at improving insulin sensitivity in diabetes or pre-diabetes or its published positive effects on brain function. This is what I was referring to with regard to B lowering high levels of artery-damaging blood homocysteine levels. This might require several times more B than is needed to correct deficiencies.
This is not to argue a point with your answer, which was fine. It is merely to request additional mention of these things in your answers. There are some situations in which very high doses of nutrients are given.
For example, high-dose niacin can lower cholesterol. High-dose fish oil can lower triglycerides. These are discussed in the relevant Reviews in the "What It Does" section. One needs to be very careful when using high doses -- there are pros and cons. Anything that has an effect probably has a side-effect. For your privacy, only your first name from your account followed by a random number will appear with your comment.
Your last name and email address will not be displayed. All rights reserved. This site is intended for informational purposes only and not to provide medical advice. Learn how to enable it here. About ConsumerLab. Contact Us Privacy Policy. Save to favorites This feature is restricted to active members. Avoid drinking large amounts of alcohol. Heavy drinking can make it harder for your body to absorb cyanocobalamin.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. This list is not complete. Other drugs may affect cyanocobalamin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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